Pfizer

🔬They Thought the Model Was Broken — Matt McPartlon & Neil Patil, Chai Discovery

Aug 11, 2026 · 1:35:20

Matt McPartland and Neil Patil of Chai Discovery explain why pharma partners like Eli Lilly, Pfizer, Novartis, and argenx are buying their AI design tools, arguing that Chai-2's all-atom diffusion model crossed a usefulness threshold by designing antibodies to 50 targets with hits on half at ~20% hit rate. They trace the lineage from open-sourced Chai-1 structure prediction through Chai-2's co-design of sequence and structure, and detail how validation via cryo-EM achieved a 0.33 Å error, making them suspect data leakage. The product resembles SolidWorks or Figma, not ChatGPT, with paint-tool epitope selection and content-aware fill for binder generation, built under strict pharma IP constraints via single-tenancy. They discuss convincing skeptical scientists—one cried after seeing a binder for a target she'd spent a decade on—and argue the compute market is mispriced for this model class, with bottlenecks in validation loops and talent obscurity rather than data or compute.

🔬 RL with Verifiable Rewards, but the Verifier is a Lab — Lila Sciences

Jul 16, 2026 · 1:41:04

Andy Beam (CTO) and Rafa Gómez-Bombarelli (Co-founder & CSO of Physical Sciences) of Lila Sciences argue that science is an 'infinite token generator' for AI, using reinforcement learning with verifiable rewards where the wet lab acts as the verifier. They claim one general model trained on ~10 trillion experimentally-verified reasoning tokens across biology, chemistry, and materials outperforms domain-specific models—'breadth gives us depth.' Their AI Science Factories treat the lab as a data center, with instruments on a 'PCI bus' and humans 'below the API line.' Highlights include a CAR-T candidate designed in six months by two or three people, 'monster UTRs' achieving ~10x Moderna/Pfizer mRNA expression, and the 'zero-FTE startup' business model. They discuss RL pathologies like collapsed chains of thought and a model that 'swears,' and note why there is still no AlphaFold for materials due to the sim-to-real gap.

⚡️ How to turn Documents into Knowledge: Graphs in Modern AI — Emil Eifrem, CEO Neo4J

Apr 18, 2026 · 48:53

Emil Eifrem, CEO of Neo4j, joins host Shawn Wang to argue that AI systems need more than top-K chunk retrieval—they require graph-shaped context for accuracy, explainability, and developer productivity. GraphRAG combines vector search with graph traversal, starting semantically then expanding through relationships, which he says yields higher accuracy and auditability than opaque vector spaces. Neo4j now powers production AI at companies like Pfizer (over 60 million documents), Novo Nordisk, and 20 of North America’s 20 largest banks, with a mortgage lender seeing a 20% conversion lift. Eifrem describes four data sources for agentic systems: operational databases, cloud warehouses, agentic memory, and context graphs—the latter encoding institutional decision traces. He notes a recent shift where enterprises lead with generic text-to-Cypher instead of specialized functions, and highlights Neo4j's new `create-context-graph` starter kit for 22 industries, built to bootstrap context graphs and agent memory.