Temporal

🔬They Thought the Model Was Broken — Matt McPartlon & Neil Patil, Chai Discovery

Aug 11, 2026 · 1:35:20

Matt McPartland and Neil Patil of Chai Discovery explain why pharma partners like Eli Lilly, Pfizer, Novartis, and argenx are buying their AI design tools, arguing that Chai-2's all-atom diffusion model crossed a usefulness threshold by designing antibodies to 50 targets with hits on half at ~20% hit rate. They trace the lineage from open-sourced Chai-1 structure prediction through Chai-2's co-design of sequence and structure, and detail how validation via cryo-EM achieved a 0.33 Å error, making them suspect data leakage. The product resembles SolidWorks or Figma, not ChatGPT, with paint-tool epitope selection and content-aware fill for binder generation, built under strict pharma IP constraints via single-tenancy. They discuss convincing skeptical scientists—one cried after seeing a binder for a target she'd spent a decade on—and argue the compute market is mispriced for this model class, with bottlenecks in validation loops and talent obscurity rather than data or compute.

⚡️ The best engineers don't write the most code. They delete the most code. — Stay Sassy

Apr 13, 2026 · 57:30

Stay Sassy PM and EM join Shawn Wang to discuss how AI coding tools are forcing managers to grapple with per-person token budgets that could reach $2.5M annually as consumption-based pricing replaces subsidies, making code review more critical, not less. They argue that managing these budgets is a new bottleneck, requiring companies to decide how much to spend on individual employees—a scale unprecedented outside department-level budgeting. On build vs buy, they caution that many products are more complex than they appear, and that the old frameworks of feature analysis, administration burden, and vendor lock-in still apply. They highlight code review fatigue from running multiple agents as a risk, citing Amazon's six-hour downtime from AI-generated code, and urge teams to maintain a culture where no single person can take down prod. Finally, they suggest automating executives' standard decisions first—since much leadership work is routine—rather than targeting only junior tasks, and predict that the hardest problems in 2026 will remain human.

Extreme Harness Engineering: 1M LOC, 1B toks/day, 0% human code or review — Ryan Lopopolo, OpenAI

Apr 7, 2026 · 1:17:54

Ryan Lopopolo of OpenAI's Frontier team details his team's extreme experiment in harness engineering: building a 1M LOC internal Electron app with zero human-written or reviewed code, relying instead on Codex agents that process 1B tokens daily ($2-3k/day). He argues that humans are the bottleneck and that teams should encode non-functional requirements into specs, skills, and observability tooling rather than prompting agents to 'try harder.' The result is Symphony, a ghost library spec and Elixir reference implementation that automates the entire pull-request lifecycle, including self-review and merge. Lopopolo explains how the team scales by treating software as agent-legible text, using worktrees for multi-agent collaboration, and feeding agent mistakes back into the repository via docs like core-beliefs.md. He also discusses Frontier's enterprise platform for safe agent deployment, noting that success depends on giving agents full context—even company culture and inside jokes—so they can act as full teammates.

⚡️ Ship AI recap: Agents, Workflows, and Python — w/ Vercel CTO Malte Ubl

Nov 1, 2025 · 42:02

Vercel CTO Malte Ubl discusses the company's AI strategy, centered on the new Workflow Development Kit that enables durable, resumable serverless functions with infinite idle time at no cost. He explains how the AI SDK was extracted from v0 and remains deliberately low-level to accommodate emerging patterns, with a direct agent abstraction now stable in version six. Ubl details Vercel's internal agents—including a DevOps agent that investigates production anomalies by querying observability data and logs, solving the recall-precision problem in alerting—and the 'Agent on Every Desk' program that helps large companies build their first three agents. He also covers zero-config Python support for Flask and FastAPI, and a security model that assumes developers cannot be trusted, extracting auth and data access from application code.